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Decreased blood pressure, syncope, and protracted erection were reported in about intelligent volunteers exposed to gamy doses of sildenafil citrate (200 to 800 mg). To diminution the take a chance of contrary reactions in patients winning ritonavir, a decrement in Viagra dose is suggested [see Dosage and Administration (2.4), Drug Interactions (7.4), and Clinical Pharmacology (12.3)]. Based on promulgated literature, the period of time incidence of NAION is 2.5 to 11.8 cases per 100,000 in males ripened ≥ 50. An experimental case-crossing over analyse evaluated the lay on the line of NAION when PDE5 inhibitor use, as a class, occurred instantly before NAION attack (inside 5 half-lives), compared to PDE5 inhibitor utilise in a prior fourth dimension geological period. The results propose an approximative 2-folding increment in the hazard of NAION, with a chance approximation of 2.15 (95% CI 1.06, 4.34).

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