Sildenafil: MedlinePlus Drug Information

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One-third base to one-half of the subjects in these studies reported successful congress at to the lowest degree erst during a 4-week, treatment-discharge run-in point. Sildenafil citrate at brace state, at a acid not approved for the treatment of erectile dysfunction (80 mg t.i.d.) resulted in a 50% increment in AUC and a 42% step-up in Cmax of bosentan (125 mg b.i.d.). In level-headed male volunteers, on that point was no evidence of a clinically meaning upshot of azithromycin (500 mg daily for 3 days) on the systemic photograph of sildenafil citrate or its John Major circulating metabolite. In addition, N-desmethyl metabolite AUC and C values significantly increased by 200% and 79%, severally in subjects with spartan excretory organ stultification compared to subjects with convention excretory organ social function. Undivided viva voce doses of sildenafil citrate up to 100 mg produced no clinically relevant changes in the ECGs of rule male volunteers.